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KMID : 0665220090220020246
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Korean Journal of Food and Nutrition
2009 Volume.22 No. 2 p.246 ~ p.251
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Hypoglycemic Effect of Angelica gigas Naki Extract in Streptozotocin-induced Diabetic Rats
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Park Man-Jong
Kang Shin-Jyung
Kim Ae-Jung
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Abstract
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This study examined the possible hypoglycemic effects Angelica gigas Naki extracts in streptozotocin-induced diabetic rats(STZ+50%, STZ+100% EtOH and STZ+water). The studies showed that administration of the Angelica gigas Naki extract decreased high blood glucose levels(more than 300 mg/) to a normal level(104 mg/) in the STZ+50% EtOH group. Liver glucokinase levels were significantly increased in STZ+50% EtOH and STZ+100% EtOH groups compared to the STZ group. Moreover, the liver acetyl CoA carboxylase level was significantly increased in STZ+50% EtOH, STZ+100% EtOH and STZ+water groups compared to the STZ group. These results suggest that the Angelica gigas Naki extract in the STZ+50% EtOH group exerted an ameliorable effect and can be used as an anti-diabetic substance, either as a dietary supplements or as a new drug.
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KEYWORD
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Angelica gigas Naki extract, ameliorable effect, streptozotocin-induced diabetes
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